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A Revolutionary Product to Maintain a Healthy Inflammatory Response

CurcuVET®

curcumin phytosome for enhanced bioavailability

A Thorne Research Exclusive:
  • Supports gastrointestinal health
  • Promotes healthy joints and muscles
  • Provides hepatic support
  • Promotes ocular health
  • Provides support for oncology patients
  • Supported by clinical studies
The Science Behind CurcuVET
Numerous studies in dogs, horses, sheep, rodents, and humans demonstrate CurcuVET's (Meriva® in the case of humans) potential for helping to maintain normal inflammatory processes.

Joint and Muscle Support
Studies demonstrate CurcuVET supports a healthy inflammatory response in small animals and horses. A recent European study analyzed the bioactivity of CurcuVET compared to non-steroidal anti-inflammatory drugs and found their bioactivity was similar. The study's sponsors, who were studying canine joint health, found CurcuVET was effective in helping to maintain the markers associated with a normal inflammatory response in canines.1

A similar equine study on the effect of CurcuVET on cytokine gene expression found maintenance of additional markers associated with a normal inflammatory response in mares and foals.2

Similar results were achieved in an eight-month human trial of Meriva. The promotion of joint health was reflected in improvements in both clinical and biochemical end points.3

Hepatic Support
Several studies have illustrated curcumin's hepatoprotective effects, leading researchers to suggest its use can protect the liver from exogenous insults from environmental toxins. Curcumin also has the capacity to increase both the flow and solubility of bile. Curcumin's hepatoprotective effects are due in part to direct free radical scavenging; but curcumin also enhances the body's natural antioxidant system, which increases glutathione levels, thereby aiding in hepatic detoxification and inhibiting nitrosamine formation. In a 2007 absorption study, liver levels of curcumin were significantly higher after dosing with the curcumin-phosphatidylcholine complex found in CurcuVET compared to conventional curcumin extracts.4

Gastrointestinal Support
Curcumin has demonstrated its potential to help maintain the body's normal inflammatory response. For example, in numerous animal studies, curcumin has shown the ability to help maintain healthy intestinal mucosa under various adverse conditions. Among the effects noted in the various trials have been decreased NF-κB, nitric oxide, and free radicals in the colonic mucosa. In two human studies in 2005 and 2006, patients who had poor gastrointestinal health demonstrated that the administration of curcumin improved overall well-being, maintained the levels of biomarkers generally associated with the body's normal inflammatory response, and served as a non-drug adjunct that did not disrupt the use of conventional medications. In addition, in a study of curcumin-phosphatidylcholine complex in humans for joint health, patients experienced a decrease in gastrointestinal complaints.3

Supports Ocular Health
In a clinical study of 106 patients with a long-term condition adversely affecting ocular health, Meriva (Curcu-VET) resulted in alleviation of signs and symptoms of eye discomfort in 80 percent of participants. It was well tolerated, improved overall quality of life, and helped maintain the eye's normal inflammatory response.5

Provides Support for Oncology Patients
A recent in vitro study on mice found that the curcumin phytosome in CurcuVET increased the receptivity of various mice cells to subsequent oxaliplatin chemotherapy. In addition, curcumin phytosome also positively increased markers associated with the desired effects of oxaliplatin chemotherapy. These results demonstrate that CurcuVET should be considered for the nutritional support of oncology patients.6

Maintains a Healthy Inflammatory Response in Ruminants
CurcuVET was shown to limit early neutrophil infiltration in vitro in sheep neutrophils, indicating it might have a place in helping to maintain a normal inflammatory response in ruminants.7

A Breakthrough in Curcumin Absorption
Phytosome Technology
  • Marked enhancement of bioavailability
  • Significantly greater clinical benefits
  • Assured delivery to the tissues
  • No compromise of nutrient safety
Thorne Research/Thorne Vet has teamed up with Indena S.p.A., the global expert in botanical extract technology, to bring veterinarians an exciting new curcumin phytosome called CurcuVET. CurcuVET provides your patients with significantly more bioavailability than any curcumin extract or compound currently available. CurcuVET is manufactured to the high quality standards you've learned to expect from Thorne and Indena.

What are phytosomes? Phytosomes are created by a patented process that binds an herbal extract to a phospholipid – in this case phosphatidylcholine, a principal element of cell membranes. This unique phytosome complex easily crosses the gut barrier, unlike common herbal extracts, and results in significantly higher blood levels than standardized 95-percent curcumin extract.

Superior Absorption Supported by Research
A 2007 study in rodents and published in the journal Cancer Chemotherapy and Pharmacology demonstrated CurcuVET's superior bioavailability, compared to ordinary curcumin. Liver levels of curcumin were also higher with CurcuVET supplementation.4 In a more recent (soon to be published) randomized, single-blind, crossover study in nine humans, total curcuminoid bioavailability, as evaluated by the plasma area under the curve (AUC), was about 29-fold higher for Meriva than for the conventional turmeric extract.

References
1. Gaspardo B, Colitti M, Scaini C, et al. Transcriptome modification of peripheral white blood cells after dietary administration of curcumin in osteoarthritic affected dogs. Plant & Animal Genomes XVIII Conference, January 2010; San Diego, CA.
2. Farinacci M, Gaspardo B, Colitti M, Stefanon B. Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes. Ital J Anim Sci 2009;8(Suppl 2):84-86.
3. Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex during extended administration in osteoarthritis patients. Altern Med Rev 2010;15:337-344.
4. Marczylo TH, Verschoyle RD, Cook DN, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 2007;60:171-177.
5. Allegri P, Mastromarino A, Neri P. Management of chronic anterior uveitis relapses: efficacy of oral phospholipid curcumin treatment. Long term follow-up. Clin Ophthalmol 2010;4:1-6.
6. Howells LM, Sale S, Sriramareddy SN, et al. Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. Int J Cancer 2010 Sept. 13. [Epub ahead of print]
7. Farinacci M, Colitti M, Stefanon B. Modulation of ovine neutrophil function and apoptosis by standardized extracts of Echinacea angustifolia, Butea frondosa and Curcuma longa. Vet Immunol Immunopathol 2009;128:366-373.

Click on the links below to order these products.

CurcuVET-SA50
CurcuVET-SA150


A Message to Our Customers

After much careful evaluation and consideration during the past year, ThorneVET has discontinued several products. Most of the discontinued products, however, still remain available in our human line. Click bottles below for more information.

Vet Express®

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ImmunoVET™

Serum Immunoglobulin Concentrate to Promote a Healthy Immune Response

CurcuVET®

A Revolutionary Product to Maintain a Healthy Inflammatory Response

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